Use of multiple genotoxicity tests to study DNA damage of chemicals in humans (in vivo) and in cell lines (in vitro). Improving methods to assess genotoxicity and mutagenicity of chemicals, e.g., developing high-throughput methods based on flow cytometry or automated methods based on imaging microscopy to assess chemically-induced mutagenic effects in exposed workers. Identifying early genotoxic events such as the formation of DNA adducts in vivo and in vitro.
PAH-induced lung and bladder cancer, e.g., in coke oven workers
health serviceType of hazard:
work-related health hazards, dangerous substancesCatchwords:
analytical methods, strain, carcinogenic substancesDescription, key words:
changed structures and funktions, genotoxicity, biological effect monitoring