List of carcinogenic, germ-cell mutagenic and reprotoxic substances

(CMR List)

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Source: IFA

The list (as of August 2022) contains CMR substances – also referred to as CMR substances (carcinogenic, mutagenic and reprotoxic) – which are

  • classified as carcinogenic, mutagenic or reprotoxic according to Table 3 of Annex VI to Table 3 of Annex VI to Regulation (EC) No 1272/2008 (GHS Regulation, CLP Regulation) up to and including Annex VI Regulation (EU) No 2020/1182,
  • listed in TRGS 905 "List of carcinogenic, germ-cell mutagenic and reprotoxic substances" or
  • listed in TRGS 906, "List of carcinogenic activities or processes according to section 3 (2) no. 3 of the German Hazardous Substances Ordinance (GefStoffV)".

It does not contain any of the complex mineral oil, coal and natural gas derivatives listed in Annex VI of Regulation 1272/2008. The classification rules under Regulation (EC) No. 1272/2008 (CLP Regulation) require a manufacturer or importer to deviate from the harmonised classification given in Annex VI if the substance is known to fall under at least one hazard class or hazard category not covered by the relevant entry in Annex VI. In such a case, an extended classification is required over and above the one given in the Annex VI entry. These self-classifications are not harmonised. If there are differences between the classification under the safety data sheet and the harmonised classification under Table 3 of Annex VI of the CLP Regulation provided in the CMR List, the classification under the safety data sheet is decisive for the implementation of measures under the German Hazardous Substances Regulation (GefStoffV). However, irrespective of this, the entries in TRGS 905 and 906 still need to be observed.

Use of database

The database may be used for the purpose of occupational health and safety or to obtain information on the hazards posed by chemical substances. Any partial or complete transfer of the list into other information systems is not permitted.


The data in the CMR List is carefully compiled and updated. Nevertheless, we cannot accept any liability, irrespective of legal grounds.


The CMR List is compiled and updated by the Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA).


CMR List (last updated: August 2022)


Dr Marco Steinhausen

Division 1: Information technology, Risk management

Tel: +49 30 13001-3150
Fax: +49 30 13001-38001