Effect monitoring is a suitable strategy for detecting biochemical and immunological effects occurring in the chain of events between exposure and a resulting health disorder. At the IPA, non-invasive methods (NIM) such as the collection and analysis of nasal lavage fluid (NALF), exhaled breath condensate (EBC) or induced sputum are increasingly being applied for the monitoring of effects caused by occupational exposure in the upper and lower respiratory tract and the lung.
Inflammatory biomarkers including differential cell counts aid in the subtyping of respiratory diseases and help to define asthma and COPD phenotypes.
Hoffmeyer F, Sucker K, Berresheim H, Monsé C, Jettkant B, beine A, Raulf M, Brüning T, Bünger J: Methodological implications and repeatability of nasal nitric oxide: Relevance for challenge studies. Adv Ep Med Biol 2019; 1113: 1-10 DOI: 10.1007/5584_2018_166
Hoffmeyer F, Weiß T, Lehnert M, Pesch B, Berresheim H, Henry J, Raulf-Heimsoth M, Broding HC, Bünger J, Harth V, Brüning T. Increased metal concentrations in exhaled breath condensate of industrial welders. J. Environ. Monit. 2011; 13: 212-218
Quirce S, Lemière C, de Blay F, Del Pozo V, Gerth Van Wijk R, Maestrelli P, Pauli G, Pignatti P, Raulf-Heimsoth M, Sastre J, Storaas T, Moscato G. Noninvasive methods for assessment of airway inflammation in occupational settings. Allergy 2010; 65: 445-458
Hoffmeyer F, Raulf-Heimsoth M, Harth V, Bünger J, Brüning T. Comparative analysis of selected exhaled breath biomarkers obtained with two different temperature-controlled devices. BMC Pulm Med 2009; 9: 48.
Hoffmeyer F, Harth V, Bünger J, Brüning T, Raulf-Heimsoth M. Leukotriene B4, 8-iso-Prostaglandin F2α and pH in exhaled breath condensate from asymptomatic smokers. J Physiol Pharmacol. 2009; 60: 57-60
